DEVELOPMENT OF HEMORRHAGIC STROKE NEUROSURGERY AT THE PRESENT STAGE (REVIEW)

Abstract

The article analyzes the current trends in the development of hemorrhagic stroke (HS) neurosurgery. The studies were conducted using the Web of Science, Scopus, PubMed, CyberLeninka, eLibrary databases by searching/analyzing sources published over three years, as well as individual publications older than five years (2014 to 2022). A total of 50 literature sources were analyzed. The article considers neurosurgical approaches to the treatment of HS and current approaches to the study of pathological mechanisms, predictors, and risk factors. It was found that much attention is paid to a comparative study of the outcomes of classical and minimally invasive methods of treating the pathology. An increase in the proportion of the latter leads to a decrease in the mortality rate in HS. Arterial hypertension is an unambiguous risk factor in the development of pathology. Many studies are devoted to potential predictors of HS outcomes (prealbumin level, hyperuricemia, lymphocyte/neutrophil ratio). Particular attention is paid to the mechanisms of formation of programmed cell deaths in the postoperative period. A list of molecular-cellular predictors optimal for risk stratification in GI has not been formed. It is necessary to search for therapeutic targets through an in-depth study of the mechanisms of development/remission of pathology at the molecular-cellular level.